13 results for "Sphingosine-1-phosphate Receptor Agonists Small Molecules and Peptides" in Products
Sphingosine-1-phosphate Receptor Agonists: Small Molecules and Peptides
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes.
Both the S1P1 and S1P3 receptors are expressed ubiquitously. The S1P2 receptor is expressed postnatally in the brain, heart, lung, stomach, intestine and adrenal ...
Cell-permeable, selective S1P1 receptor agonist
| Chemical Name: | 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole |
| Purity: | ≥98% (HPLC) |
Potent S1P receptor agonist; also immunosuppressant
| Alternate Names: | Fingolimod,Gilenya |
| Chemical Name: | 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective S1P1 receptor agonist
| Chemical Name: | 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride |
| Purity: | ≥98% (HPLC) |
Endogenous agonist at S1P1-5
| Chemical Name: | (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol |
| Purity: | ≥98% (HPLC) |
Selective S1P3 receptor allosteric agonist
| Chemical Name: | N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide |
| Purity: | ≥97% (HPLC) |
Selective S1P2 allosteric agonist
| Chemical Name: | 1-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-3-pyridinecarbonitrile |
| Purity: | ≥98% (HPLC) |
Potent S1P1 agonist
| Chemical Name: | N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective S1P1 agonist
| Chemical Name: | 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid |
| Purity: | ≥97% (HPLC) |
Potent and selective S1P4 agonist
| Chemical Name: | (2Z,5Z)-5-[[1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone |
| Purity: | ≥98% (HPLC) |
Potent and selective S1P1 and S1P5 agonist
| Chemical Name: | 5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile |
| Purity: | ≥98% (HPLC) |
S1P1 and S1P5 agonist
| Chemical Name: | 4-[5-[5-Chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective S1P4 agonist
| Chemical Name: | 2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine |
| Purity: | ≥98% (HPLC) |
Potent and selective S1P5 agonist
| Chemical Name: | 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
