FTY 720

Tocris Bioscience, part of Bio-Techne | Catalog # 6176

Potent S1P receptor agonist; also immunosuppressant
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Key Product Details

Description

Potent S1P receptor agonist; also immunosuppressant

Alternative Names

Fingolimod,Gilenya

View all Sphingosine-1-phosphate Receptor Agonists »

Product Description

FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

Product Specifications

Molecular Weight

343.93

Formula

C19H33NO2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

CAS Number

162359-56-0

PubChem ID

107969

InChI Key

SWZTYAVBMYWFGS-UHFFFAOYSA-N

SMILES

CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 34.39 100
DMSO 34.39 100

Preparing Stock Solutions for FTY 720

The following data is based on the product molecular weight 343.93

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.54 mL 29.08 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.45 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for FTY 720

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FTY 720

For research use only

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