FTY 720

Tocris Bioscience, part of Bio-Techne | Catalog # 6176

COA / SDS

Potent S1P receptor agonist; also immunosuppressant

Key Product Details

Description:	Potent S1P receptor agonist; also immunosuppressant
Alternative Names:	Fingolimod,Gilenya
Chemical Name:	2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	343.93

View Full Technical Details for FTY 720

Technical Data
Citations

Biological Activity for FTY 720

FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P₁,₃,₄ and ₅ receptors (EC₅₀ values are 0.3 - 0.6 nM for S1P₁, ₄ and ₅ and ~3 nM for S1P₃). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

Compound Libraries for FTY 720

FTY 720 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for FTY 720

M. Wt	343.93
Formula	C₁₉H₃₃NO₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	162359-56-0
PubChem ID	107969
InChi Key	SWZTYAVBMYWFGS-UHFFFAOYSA-N
Smiles	CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FTY 720

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	34.39	100
	DMSO	34.39	100

Preparing Stock Solutions for FTY 720

The following data is based on the product molecular weight 343.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.54 mL	29.08 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
10 mM	0.29 mL	1.45 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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Reconstitution Calculator

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References for FTY 720

References are publications that support the biological activity of the product.

Shiow CD69 acts downstream of IF.-alpha/beta to inhibit S1P₁ and lymphocyte egress from lymphoid organs. Nature 2006 PMID: 16525420
Brinkmann Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 2010 PMID: 21031003
Coelho The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J.Pharmacol.Exp.Ther. 2007 PMID: 17726159
Hopkins ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720). ACS Chem. Neurosci. 2011 PMID: 22778861