CYM 5541

Name: CYM 5541
Brand: Tocris Bioscience
SKU: 4897

Tocris Bioscience, part of Bio-Techne | Catalog # 4897

Citations (29)

COA / SDS

Selective S1P3 receptor allosteric agonist

Key Product Details

Description:	Selective S1P₃ receptor allosteric agonist
Chemical Name:	N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Purity:	≥97% (HPLC)
Molecular Weight:	316.44

View Full Technical Details for CYM 5541

Technical Data
Citations

Biological Activity for CYM 5541

CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P₃) allosteric agonist (EC₅₀ = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P₃ than S1P. Displays no activity at S1P₁, S1P₂, S1P₄ and S1P₅ receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

Compound Libraries for CYM 5541

CYM 5541 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CYM 5541

M. Wt	316.44
Formula	C₁₉H₂₈N₂O₂
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	945128-26-7
PubChem ID	17253208
InChi Key	NDKGACIWVAOUQH-UHFFFAOYSA-N
Smiles	O=C(N(C3CCCCC3)C2CCCCC2)C1=NOC(C4CC4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CYM 5541

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.64	100
	ethanol	15.82	50

Preparing Stock Solutions for CYM 5541

The following data is based on the product molecular weight 316.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.80 mL	31.60 mL
5 mM	0.63 mL	3.16 mL	6.32 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for CYM 5541

References are publications that support the biological activity of the product.

Jo Novel selective allosteric and bitopic ligands for the S1P₃ receptor. ACS Chem.Biol. 2012 PMID: 22971058