Presenilin-1 Products
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
211 results for "Presenilin-1" in Products
211 results for "Presenilin-1" in Products
Presenilin-1 Products
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester |
| Purity: | ≥99% (HPLC) |
γ-secretase inhibitor; inhibits Notch pathway
| Alternate Names: | Dibenzazepine,YO-01027 |
| Chemical Name: | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| Purity: | ≥98% (HPLC) |
DAPT synthesized to Ancillary Material Grade
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester |
| Purity: | ≥99% |
Contains 4 membranes - each spotted in duplicate with 35 different protease antibodies
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #APS 18 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
![Western Blot: Presenilin-1 Antibody (APS 18) [NB100-74510]](https://resources.bio-techne.com/images/products/Presenilin-1-Antibody-APS-18-Western-Blot-NB100-74510-img0013.jpg "Western Blot: Presenilin-1 Antibody (APS 18) [NB100-74510]")
γ-secretase pseudo-inhibitor
| Chemical Name: | (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide |
| Purity: | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name: | (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide |
| Purity: | ≥98% (HPLC) |
Highly potent γ-secretase inhibitor; orally bioavailable
| Alternate Names: | BMS-708163 |
| Chemical Name: | (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide |
| Purity: | ≥98% (HPLC) |
γ-secretase inhibitor; attenuates amyloid plaque deposition
| Chemical Name: | N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name: | 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, KO |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #121121 |
| Applications: | WB, IHC |
Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: Presenilin-1 AntibodyBSA Free [NBP1-76792]](https://resources.bio-techne.com/images/products/Presenilin-1-Antibody-Western-Blot-NBP1-76792-img0002.jpg "Western Blot: Presenilin-1 AntibodyBSA Free [NBP1-76792]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #121121 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #121121 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #121121 |
| Applications: | WB, IHC |
| Applications: | WB, ELISA, MA, AP, PAGE |
![SDS-PAGE: Recombinant Human Presenilin-1 GST (N-Term) Protein [H00005663-Q01]](https://resources.bio-techne.com/images/products/qc_test-H00005663-Q01-1.jpg "SDS-PAGE: Recombinant Human Presenilin-1 GST (N-Term) Protein [H00005663-Q01]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #121130 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunohistochemistry-Paraffin: Presenilin-1 Antibody [NBP1-33611]](https://resources.bio-techne.com/images/products/Presenilin-1-Antibody-Immunohistochemistry-Paraffin-NBP1-33611-img0011.jpg "Immunohistochemistry-Paraffin: Presenilin-1 Antibody [NBP1-33611]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, KO |