BMS 299897
Tocris Bioscience, part of Bio-Techne | Catalog # 2870
Potent γ-secretase inhibitor
Product Description
BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.Product Specifications
Molecular Weight
511.94
Formula
C24H21ClF3NO4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid
CAS Number
290315-45-6
PubChem ID
11249248
InChI Key
IZAOBRWCUGOKNH-OAHLLOKOSA-N
SMILES
FC1=CC=[C@@]([C@H](N(C3=CC(F)=CC=C3F)S(C2=CC=C(Cl)C=C2)(=O)=O)C)C(CCCC(O)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.19 | 100 | |
| Ethanol | 51.19 | 100 |
Preparing Stock Solutions
for BMS 299897
The following data is based on the product molecular weight 511.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.77 mL | 19.53 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.91 mL |
| 10 mM | 0.20 mL | 0.98 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Anderson Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897. Biochem.Pharmacol. 2005 PMID: 15670587
- Goldstein Ex vivo occupancy of the γ-secretase inhibitors correlates with brain β-amyloid peptide reduction in Tg2576 mice. J.Pharmacol.Exp.Ther. 2007 PMID: 17640949
- Barten Dynamics of β-Amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor. J.Pharmacol.Exp.Ther. 2005 PMID: 15452193
Product Specific Notices for BMS 299897
For research use only
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