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Histone Deacetylase 4/HDAC4: Small Molecules and Peptides

Histone Deacetylase (HDAC) family includes 18 enzymes. They are classified into two groups: the histone deacetylase family and the sirtuin family. The histone deacetylase family is divided into classes I, II and IV.

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10 results for "Histone Deacetylase 4/HDAC4 Small Molecules and Peptides" in Products

10 results for "Histone Deacetylase 4/HDAC4 Small Molecules and Peptides" in Products

Histone Deacetylase 4/HDAC4: Small Molecules and Peptides

Histone Deacetylase (HDAC) family includes 18 enzymes. They are classified into two groups: the histone deacetylase family and the sirtuin family. The histone deacetylase family is divided into classes I, II and IV.

Products:

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Histone deacetylase inhibitor

Alternate Names: 4-PB,Sodium phenylbutyrate
Chemical Name: 4-Phenylbutyric acid, sodium salt
Purity: ≥98% (HPLC)
Histone deacetylase inhibitor

Potent and selective HDAC4 Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((3R,26S)-26-(tert-Butyl)-3-methyl-1,24-dioxo-5-propyl-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-10,13,16,19,22-pentaoxa-2,5,25-triazaheptacosan-27-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Potent and selective HDAC4 Degrader (PROTAC®)

Histone deacetylase inhibitor

Alternate Names: VPA,Sodium Valproate
Chemical Name: Sodium 2-propylpentanoate
Histone deacetylase inhibitor

Potent histone deacetylase inhibitor

Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Purity: ≥95% (HPLC)
Potent histone deacetylase inhibitor

Potent and selective class I histone deacetylase inhibitor; antitumor

Alternate Names: Depsipeptide,FR 901228,Romidepsin
Chemical Name: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5) disulfide
Purity: ≥98% (HPLC)
Potent and selective class I histone deacetylase inhibitor; antitumor

Pan-histone deacetylase inhibitor

Chemical Name: (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
Purity: ≥98% (HPLC)
Pan-histone deacetylase inhibitor

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

Chemical Name: 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide
Purity: ≥98% (HPLC)
High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

Class I and II HDAC inhibitor

Alternate Names: Vorinostat
Chemical Name: N-Hydroxy-N'-phenyloctanediamide
Purity: ≥98% (HPLC)
Class I and II HDAC inhibitor

Potent and selective HDAC class IIa inhibitor

Chemical Name: N-((R)-1-((S)-2-Methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Purity: ≥98% (HPLC)
Potent and selective HDAC class IIa inhibitor

Potent and selective class IIa HDAC inhibitor; brain penetrant

Chemical Name: 2-(2-Fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide
Purity: ≥98% (HPLC)
Potent and selective class IIa HDAC inhibitor; brain penetrant
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