RGFP 966

Name: RGFP 966
Brand: Tocris Bioscience
SKU: 6728

Tocris Bioscience, part of Bio-Techne | Catalog # 6728

Citations (6)

COA / SDS

Potent and selective HDAC3 inhibitor

Key Product Details

Description:	Potent and selective HDAC3 inhibitor
Chemical Name:	(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Purity:	≥98% (HPLC)
Molecular Weight:	362.4

View Full Technical Details for RGFP 966

Technical Data
Citations

Biological Activity for RGFP 966

RGFP 966 is a potent and selective HDAC3 inhibitor (IC₅₀ = 80 nM); exhibits no effect on other HDAC (up to 15 μM). RGFP 966 reduces the frequency of striatal CAG repeat expansions in mouse models of Huntington's disease and reduces mHTT accumulation. RGFP 966 blocks the formation of reactive astrocytes and, in vivo, it is neuroprotective and enhances long-term object-location memory.

Compound Libraries for RGFP 966

RGFP 966 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for RGFP 966

M. Wt	362.4
Formula	C₂₁H₁₉FN₄O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1357389-11-7
PubChem ID	56650312
InChi Key	BLVQHYHDYFTPDV-VCABWLAWSA-N
Smiles	NC1=C(C=CC(F)=C1)NC(/C=C/C2=CN(N=C2)C/C=C/C3=CC=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RGFP 966

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.24	100

Preparing Stock Solutions for RGFP 966

The following data is based on the product molecular weight 362.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.80 mL	27.59 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for RGFP 966

References are publications that support the biological activity of the product.

Suelvez A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice. Sci.Rep. 2017 PMID: 28729730
Clayton A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity. Nat.Neurosci. 2024 PMID: 38378993
Malvaez HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc.Natl.Acad.Sci.USA. 2013 PMID: 23297220