HDAC4 CHDI Degrader 11
Tocris Bioscience, part of Bio-Techne | Catalog # 7882
Potent and selective HDAC4 Degrader (PROTAC®)
Key Product Details
Description
Potent and selective HDAC4 Degrader (PROTAC®)
Product Description
HDAC4 CHDI Degrader 11 is a potent and selective HDAC4 Degrader (PROTAC®) (DC50 values are 4 and 6 nM in Jurkat E6-1 and Jurkat cells respectively). Comprises the class IIa HDAC inhibitor trifluoromethyloxadiazole joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein. In a mouse cell model of Huntington's disease, HDAC4 CHDI Degrader 11 potently degrades HDAC4 (DC50 = 1nM). Can be used with P-glycoprotein inhibitor Elacridar (Cat. No. 4646) for more effective degradation in neuroblastoma cell lines.HDAC4 antibody validated for Simple Western™ (automated Western) instruments also available: Catalog # NBP2-22151.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
1075.26
Formula
C52H73F3N8O11S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4R)-1-((3R,26S)-26-(tert-Butyl)-3-methyl-1,24-dioxo-5-propyl-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-10,13,16,19,22-pentaoxa-2,5,25-triazaheptacosan-27-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
3035189-46-6
InChI Key
KBDZFZJFGKYVBZ-KLSSUPLUSA-N
SMILES
O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(COCCOCCOCCOCCOCCCCN(C[C@H](NC(C4=CC=C(C=C4)C5=NOC(C(F)(F)F)=N5)=O)C)CCC)=O)C(C)(C)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.76 | 50 |
Preparing Stock Solutions
for HDAC4 CHDI Degrader 11
The following data is based on the product molecular weight 1075.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.86 mL | 9.30 mL | 18.60 mL |
| 2.5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 5 mM | 0.19 mL | 0.93 mL | 1.86 mL |
| 25 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Macabuag Developing HDAC4-selective protein degraders to investigate the role of HDAC4 in Huntington's disease pathology. J.Med.Chem. 2022 PMID: 36098485
Product Specific Notices for HDAC4 CHDI Degrader 11
For research use only
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