Sodium 4-Phenylbutyrate

Name: Sodium 4-Phenylbutyrate
Brand: Tocris Bioscience
SKU: 2682

Tocris Bioscience, part of Bio-Techne | Catalog # 2682

Citations (13)

COA / SDS

Histone deacetylase inhibitor

Key Product Details

Description:	Histone deacetylase inhibitor
Alternative Names:	4-PB,Sodium phenylbutyrate
Chemical Name:	4-Phenylbutyric acid, sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	186.18

View Full Technical Details for Sodium 4-Phenylbutyrate

Technical Data
Citations

Biological Activity for Sodium 4-Phenylbutyrate

Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Sodium 4-Phenylbutyrate also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.

Compound Libraries for Sodium 4-Phenylbutyrate

Sodium 4-Phenylbutyrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Sodium 4-Phenylbutyrate

M. Wt	186.18
Formula	C₁₀H₁₁NaO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1716-12-7
PubChem ID	5258
InChi Key	VPZRWNZGLKXFOE-UHFFFAOYSA-M
Smiles	[Na+].[O-]C(=O)CCCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sodium 4-Phenylbutyrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	18.61	100
	DMSO	4.65	25

Preparing Stock Solutions for Sodium 4-Phenylbutyrate

The following data is based on the product molecular weight 186.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.37 mL	26.86 mL	53.71 mL
5 mM	1.07 mL	5.37 mL	10.74 mL
10 mM	0.54 mL	2.69 mL	5.37 mL
50 mM	0.11 mL	0.54 mL	1.07 mL

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Reconstitution Calculator

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References for Sodium 4-Phenylbutyrate

References are publications that support the biological activity of the product.

Khan HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int.J.Mol.Med. 2011 PMID: 21894430
Ammerpohl Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br.J.Cancer 2007 PMID: 17164759
Engelhard Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. J.Neuro-Oncol. 1998 PMID: 9524087
Appelskog Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells. Int.J.Oncol. 2004 PMID: 15138583