VHL/ELOB/ELOC/CUL2/RBX1 Complex: Small Molecules and Peptides

dTAG^V-1

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate trifluoroacetate
Purity:	≥98% (HPLC)

dTAG^V-1-NEG

Catalog #: 6915

Citations (9)

Product Documents

Negative control for dTAGV-1 (Cat. No. 6914)

Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2R,4S)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity:	≥98% (HPLC)

xStAx-VHLL

Catalog #: 7298

Product Documents

Selective peptide-based β-catenin Degrader (PROTAC®)

Purity:

≥95% (HPLC)

dTAG^V-1 hydrochloride

Catalog #: 7374

(1)

Citations (3)

Product Documents

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride
Purity:	≥98% (HPLC)

LC 2

Catalog #: 7420

Citations (1)

Product Documents

Selective KRAS Degrader (PROTAC®)

Chemical Name:	(2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)

VH 298

Catalog #: 6156

Citations (9)

Product Documents

High-affinity inhibitor of VHL

Chemical Name:	(2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

ARCC 4

Catalog #: 7254

Citations (6)

Product Documents

Potent and selective androgen receptor Degrader (PROTAC®)

Chemical Name:	(2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

TBK1 PROTAC^® 3i

Catalog #: 7259

Citations (3)

Product Documents

Potent TANK-binding kinase 1 (TBK1) PROTAC®

Chemical Name:	(2S,4R)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

VH 101 phenol-alkylC6-amine

Catalog #: 7294

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:	(2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 101 phenol-alkylC4-amine

Catalog #: 7293

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:	(2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-alkylC2-amine

Catalog #: 6852

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C2-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(3-Aminopropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-alkylC2-acid

Catalog #: 7106

Product Documents

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C2-COOH
Chemical Name:	4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-PEG6-amine

Catalog #: 7568

Product Documents

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG6-NH₂
Chemical Name:	(2S,4R)-1-((S)-23-Amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-PEG5-acid

Catalog #: 7105

Product Documents

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG5-COOH
Chemical Name:	(S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid
Purity:	≥95% (HPLC)

MS 39

Catalog #: 7397

Citations (1)

Product Documents

Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR

Chemical Name:	(2S,4R)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

CM 11

Catalog #: 6416

Citations (1)

Product Documents

Homo-PROTAC® for self-degradation of pVHL30

Chemical Name:	N¹,N²⁰-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
Purity:	≥98% (HPLC)

VH 032 amide-PEG2-acid

Catalog #: 7214

Product Documents

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG2-COOH
Chemical Name:	3-(2-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)ethoxy)propanoic acid
Purity:	≥95% (HPLC)

SJF 0628

Catalog #: 7463

Citations (1)

Product Documents

Potent BRAF Degrader (PROTAC®)

Chemical Name:	(2S,4R)-1-((S)-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

VH 032 amide-alkylC3-amine

Catalog #: 7073

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C3-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(4-Aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-PEG1-acid

Catalog #: 7104

Product Documents

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG1-COOH
Chemical Name:	3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-alkylC3-acid

Catalog #: 7216

Product Documents

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C3-COOH
Chemical Name:	5-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-alkylC9-amine

Catalog #: 7566

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C9-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(10-Aminodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-alkylC5-acid

Catalog #: 7217

Product Documents

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C5-COOH
Chemical Name:	7-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid
Purity:	≥95% (HPLC)

MS 154N

Catalog #: 7396

Product Documents

Negative control for MS 154 (Cat No. 7395)

Chemical Name:	3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Purity:	≥98% (HPLC)

SJFδ

Catalog #: 7267

Product Documents

Potent and selective p38δ PROTAC®

Chemical Name:	N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Purity:	≥98% (HPLC)

VHL/ELOB/ELOC/CUL2/RBX1 Complex: Small Molecules and Peptides

dTAG^V-1

dTAG^V-1-NEG

xStAx-VHLL

dTAG^V-1 hydrochloride

LC 2

VH 298

ARCC 4

TBK1 PROTAC^® 3i

VH 101 phenol-alkylC6-amine

VH 101 phenol-alkylC4-amine

VH 032 amide-alkylC2-amine

VH 032 amide-alkylC2-acid

VH 032 amide-PEG6-amine

VH 032 amide-PEG5-acid

MS 39

CM 11

VH 032 amide-PEG2-acid

SJF 0628

VH 032 amide-alkylC3-amine

VH 032 amide-PEG1-acid

VH 032 amide-alkylC3-acid

VH 032 amide-alkylC9-amine

VH 032 amide-alkylC5-acid

MS 154N

SJFδ

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VHL/ELOB/ELOC/CUL2/RBX1 Complex: Small Molecules and Peptides

dTAGV-1

dTAGV-1-NEG

xStAx-VHLL

dTAGV-1 hydrochloride

LC 2

VH 298

ARCC 4

TBK1 PROTAC® 3i

VH 101 phenol-alkylC6-amine

VH 101 phenol-alkylC4-amine

VH 032 amide-alkylC2-amine

VH 032 amide-alkylC2-acid

VH 032 amide-PEG6-amine

VH 032 amide-PEG5-acid

MS 39

CM 11

VH 032 amide-PEG2-acid

SJF 0628

VH 032 amide-alkylC3-amine

VH 032 amide-PEG1-acid

VH 032 amide-alkylC3-acid

VH 032 amide-alkylC9-amine

VH 032 amide-alkylC5-acid

MS 154N

SJFδ

dTAG^V-1

dTAG^V-1-NEG

dTAG^V-1 hydrochloride

TBK1 PROTAC^® 3i