VEGFR2/KDR/Flk-1: Small Molecules and Peptides
VEGFR2/KDR/Flk-1 (vascular endothelial growth factor receptor 2) is a transmembrane receptor tyrosine kinase that mediates the angiogenic effects of VEGF-A and VEGF-C. It is expressed primarily on vascular endothelial cells and endothelial cell progenitors.
It is also expressed on endometrial epithelium, hematopoietic stem cells, liver sinusoidal endothelial cells, Sertoli cells and Leydig cells, platelets and megakaryocytes, sensory and autonomic neurons, Schwann cells, Muller glial cells, retinal progenitors, and osteoblasts. VEGFR2 can be associated with VEGFR1, and a soluble form of VEGFR2 can circulate in the serum.
Products:
17 results for "VEGFR2/KDR/Flk-1 Small Molecules and Peptides" in Products
17 results for "VEGFR2/KDR/Flk-1 Small Molecules and Peptides" in Products
VEGFR2/KDR/Flk-1: Small Molecules and Peptides
VEGFR2/KDR/Flk-1 (vascular endothelial growth factor receptor 2) is a transmembrane receptor tyrosine kinase that mediates the angiogenic effects of VEGF-A and VEGF-C. It is expressed primarily on vascular endothelial cells and endothelial cell progenitors.
It is also expressed on endometrial epithelium, hematopoietic stem cells, liver sinusoidal endothelial cells, Sertoli cells and Leydig cells, platelets and megakaryocytes, sensory and autonomic neurons, Schwann cells, Muller glial cells, retinal progenitors, and osteoblasts. VEGFR2 can be associated with VEGFR1, and a soluble form of VEGFR2 can circulate in the serum.
Products:
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
| Alternate Names: | Semaxinib |
| Chemical Name: | 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
| Purity: | ≥98% (HPLC) |
Potent VEGFR, PDGFR and FGFR inhibitor
| Chemical Name: | Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate |
| Purity: | ≥98% |
Dual site Src kinase inhibitor
| Chemical Name: | 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine |
| Purity: | ≥98% (HPLC) |
c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
| Chemical Name: | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea |
| Purity: | ≥97% (HPLC) |
Potent VEGFR inhibitor; also aromatase inhibitor
| Alternate Names: | CGP 79787D,PTK787/ZK222584 |
| Chemical Name: | N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate |
| Purity: | ≥98% (HPLC) |
Potent VEGFR inhibitor; also inhibits other RTKs
| Alternate Names: | Cabozantinib,BMS 907351 |
| Chemical Name: | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Purity: | ≥98% (HPLC) |
Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
| Chemical Name: | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea |
| Purity: | ≥98% (HPLC) |
Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity
| Chemical Name: | N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine |
| Purity: | ≥98% (HPLC) |
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
| Chemical Name: | 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
Inhibitor of mutant β-catenin signaling in hepatocellular carcinoma
| Chemical Name: | 4-[3-Fluoro-4-[[[[4-(1,1,2,2,2-pentafluoroethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent, selective VEGFR-2 inhibitor
| Chemical Name: | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea |
| Purity: | ≥97% (HPLC) |
Potent VEGFR, PDGFRβ and KIT inhibitor
| Alternate Names: | SU 11248 |
| Chemical Name: | N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt |
| Purity: | ≥98% (HPLC) |
Potent VEGFR-1, -2 and -3 inhibitor
| Chemical Name: | N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide |
| Purity: | ≥98% (HPLC) |
Src tyrosine kinase inhibitor
| Chemical Name: | N-(2-Chloro-5-methoxyphenyl)-6-methoxy |
| Purity: | ≥98% (HPLC) |
Potent EGFR and VEGFR inhibitor
| Chemical Name: | 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
Potent, selective inhibitor of VEGFR-2
| Chemical Name: | 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent inhibitor of VEGFR, PDGFR and FGFR
| Chemical Name: | 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline |
| Purity: | ≥98% (HPLC) |
