ZM 323881 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2475
Potent, selective inhibitor of VEGFR-2
Key Product Details
Description
Potent, selective inhibitor of VEGFR-2
Product Description
ZM 323881 hydrochloride is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
411.86
Formula
C22H18FN3O2.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride
CAS Number
193000-39-4
PubChem ID
22624897
InChI Key
AVRHWGLIYGJSOD-UHFFFAOYSA-N
SMILES
Cl.CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.59 | 50 |
Preparing Stock Solutions
for ZM 323881 hydrochloride
The following data is based on the product molecular weight 411.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.86 mL | 24.28 mL | 48.56 mL |
| 2.5 mM | 0.97 mL | 4.86 mL | 9.71 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 25 mM | 0.10 mL | 0.49 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Endo Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J.Recept.Signal Transduct.Res. 2003 PMID: 14626450
- Whittles ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 2002 PMID: 12483548
Product Specific Notices for ZM 323881 hydrochloride
For research use only
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