SU 5416

Tocris Bioscience, part of Bio-Techne | Catalog # 3037

COA / SDS

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

Key Product Details

Description:	VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
Alternative Names:	Semaxinib
Chemical Name:	3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	238.28

View Full Technical Details for SU 5416

Technical Data
Citations

Biological Activity for SU 5416

SU 5416, an angiogenesis inhibitor, is a potent vascular endothelial growth factor receptor tyrosine kinase 1/2 inhibitor (IC₅₀ = 40 nM). SU 5416 also potently inhibits c-Kit, FLT3 and RET tyrosine kinases (IC₅₀ values are 30 nM, 160 nM and 170 nM, respectively). SU 5416 shows inhibition of tumour growth and vascularization and can be used to generate an animal model of pulmonary arterial hypertension.

Compound Libraries for SU 5416

SU 5416 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SU 5416

M. Wt	238.28
Formula	C₁₅H₁₄N₂O
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	204005-46-9
PubChem ID	5329098
InChi Key	WUWDLXZGHZSWQZ-WQLSENKSSA-N
Smiles	O=C2NC1=CC=CC=C1/C2=C/C3=C(C)C=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 5416

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.83	100

Preparing Stock Solutions for SU 5416

The following data is based on the product molecular weight 238.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.20 mL	20.98 mL	41.97 mL
5 mM	0.84 mL	4.20 mL	8.39 mL
10 mM	0.42 mL	2.10 mL	4.20 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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References for SU 5416

References are publications that support the biological activity of the product.

Ciuclan A novel murine model of severe pulmonary arterial hypertension. Am.J.Respir.Crit. Care Med. 2011 PMID: 21868504
Smolich The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-Kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood 2001 PMID: 11222388
Mologni Inhibition of RET tyrosine kinase by SU5416. J.Mol.Endocrinol. 2006 PMID: 17032739
Fong SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularisation, and growth of multiple tumor types. Cancer Res. 1999 PMID: 9892193