40 results for "Ubiquitin Ligase (E3) Inhibitors Small Molecules and Peptides" in Products
Ubiquitin Ligase (E3) Inhibitors: Small Molecules and Peptides
HECT E3 ubiquitin ligase inhibitor
| Chemical Name: | N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide |
| Purity: | ≥98% (HPLC) |
SPOP E3 ubiquitin ligase inhibitor
| Chemical Name: | 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide |
| Purity: | ≥98% (HPLC) |
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
| Chemical Name: | 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione |
| Purity: | ≥98% (HPLC) |
MDM2-p53 interaction inhibitor
| Alternate Names: | NSC 652287 |
| Chemical Name: | 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol |
| Purity: | ≥97% (HPLC) |
Selective Skp2 inhibitor; suppresses E3 ligase activity
| Chemical Name: | 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
CHIP/STUB1 E3 ligase inhibitor
| Purity: | ≥95% (HPLC) |
Cereblon binder; also TNF-α inhibitor and antiangiogenic
| Chemical Name: | 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥98% (HPLC) |
β-TrCP1 ligase inhibitor
| Chemical Name: | 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid |
| Purity: | ≥98% (HPLC) |
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
| Chemical Name: | 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid |
| Purity: | ≥98% (HPLC) |
VHL inhibitor
| Chemical Name: | (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥97% (HPLC) |
MDM2 antagonist; inhibits MDM2-p53 interaction
| Chemical Name: | (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one |
| Purity: | ≥98% (HPLC) |
Molecular glue; pre-mRNA splicing modulator
| Chemical Name: | N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide |
| Purity: | ≥98% (HPLC) |
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
| Chemical Name: | N-(4-Butyl-2-methylphenyl)acetamide |
| Purity: | ≥98% (HPLC) |
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
| Chemical Name: | 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione |
| Purity: | ≥98% (HPLC) |
(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4
| Chemical Name: | (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
High-affinity inhibitor of VHL
| Chemical Name: | (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Inhibitor of VHL; blocks interaction of VHL and HIF-α
| Chemical Name: | (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Potent, selective and reversible DCN1-UBC12 interaction inhibitor
| Chemical Name: | 5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1H-tetrazole-1-ethanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
TRAF6-Ubc13 interaction inhibitor
| Chemical Name: | 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone |
| Purity: | ≥98% (HPLC) |
Selective CUL4 inhibitor
| Chemical Name: | 3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
High affinity MDM2 inhibitor
| Chemical Name: | 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole |
| Purity: | ≥98% (HPLC) |
MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction
| Chemical Name: | N1-((1H-Indol-5-yl)methyl)-N3-(quinolin-4-yl)propane-1,3-diamine |
| Purity: | ≥98% (HPLC) |
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
| Chemical Name: | 4-[[(4S,5R)-4,5-bis(4-Chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone |
| Purity: | ≥97% (HPLC) |
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
| Chemical Name: | 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide |
| Purity: | ≥98% (HPLC) |
Potent and selective CSN5 (COP9 signalosome) inhibitor
| Chemical Name: | 3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide |
| Purity: | ≥98% (HPLC) |
