Apcin

Name: Apcin
Brand: Tocris Bioscience
SKU: 5747

Tocris Bioscience, part of Bio-Techne | Catalog # 5747

Citations (21)

COA / SDS

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Key Product Details

Description:	Cdc20 inhibitor; inhibits Cdc20-substrate interaction
Chemical Name:	3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
Purity:	≥98% (HPLC)
Molecular Weight:	438.65

View Full Technical Details for Apcin

Technical Data
Citations

Biological Activity for Apcin

Apcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.

Technical Data for Apcin

M. Wt	438.65
Formula	C₁₃H₁₄Cl₃N₇O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	300815-04-7
PubChem ID	2830389
InChi Key	ZEXHXVOGJFGTRX-UHFFFAOYSA-N
Smiles	CC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Apcin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.87	100

Preparing Stock Solutions for Apcin

The following data is based on the product molecular weight 438.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.80 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Apcin

References are publications that support the biological activity of the product.

Wang Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 2015 PMID: 25850036
Sackton Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 2014 PMID: 25156254