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14 results for "Small G Protein Inhibitors" in Products

Small G Protein Inhibitors Products

Like Gα proteins, small GTPases alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP) and so function as binary switches that regulate cytosolic signaling pathways. GDP/GTP cycling is controlled by two types of regulatory proteins that associate with small GTPases. Guanine exchange factors (GEFs) promote the formation of the active, GTP bound form of RAS proteins while GTPase activating proteins (GAPs) accelerate GTPase activity, promoting the inactive, GDP bound form.

Potent Rac family inhibitor

Chemical Name: 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
Purity: ≥98% (HPLC)
Potent Rac family inhibitor

Selective inhibitor of Rac1-GEF interaction; antioncogenic

Chemical Name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
Purity: ≥98% (HPLC)
Selective inhibitor of Rac1-GEF interaction; antioncogenic

Potent farnesyl diphosphate (FPP) synthase inhibitor

Alternate Names: Zometa
Chemical Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Purity: ≥98% (HPLC)
Potent farnesyl diphosphate (FPP) synthase inhibitor

Selective Cdc42 Rho family inhibitor

Alternate Names: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Purity: ≥98% (HPLC)
Selective Cdc42 Rho family inhibitor

Epac inhibitor

Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
Purity: ≥98% (HPLC)
Epac inhibitor

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Purity: ≥98% (HPLC)
ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

Rac inhibitor

Chemical Name: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Rac inhibitor

Rho inhibitor

Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Purity: ≥98% (HPLC)
Rho inhibitor

DOCK2-Rac1 interaction inhibitor

Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Purity: ≥98% (HPLC)
DOCK2-Rac1 interaction inhibitor

Ras signaling inhibitor; inhibits Ack1 and GCK

Chemical Name: N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)
Ras signaling inhibitor; inhibits Ack1 and GCK

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

Chemical Name: [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone
Purity: ≥98% (HPLC)
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

Selective ARF6 inhibitor

Chemical Name: 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Purity: ≥98% (HPLC)
Selective ARF6 inhibitor

Selective Epac2 inhibitor

Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Purity: ≥98% (HPLC)
Selective Epac2 inhibitor

High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ

Chemical Name: 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride
Purity: ≥98% (HPLC)
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
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