CPYPP
Tocris Bioscience, part of Bio-Techne | Catalog # 4568
DOCK2-Rac1 interaction inhibitor
Product Description
CPYPP is a DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.Product Specifications
Molecular Weight
324.76
Formula
C18H13ClN2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
CAS Number
310460-39-0
PubChem ID
2248187
InChI Key
VVZJFICTTKPNCK-XWDZFIQBSA-N
SMILES
O=C(N(C3=CC=CC=C3)NC2=O)/C2=C\C=C\C1=C(Cl)C=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.5 | 20 |
Preparing Stock Solutions
for CPYPP
The following data is based on the product molecular weight 324.76
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.40 mL | 76.98 mL | 153.96 mL |
| 1 mM | 3.08 mL | 15.40 mL | 30.79 mL |
| 2 mM | 1.54 mL | 7.70 mL | 15.40 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Laurin Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23592719
- Nishikimi Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 2012 PMID: 22520755
Product Specific Notices for CPYPP
For research use only
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