ESI 09
Tocris Bioscience, part of Bio-Techne | Catalog # 4773
Epac inhibitor
Product Description
ESI 09 is an EPAC inhibitor. Inhibits EPAC-mediated insulin release from pancreatic β cells. Selective for EPAC over PKA. ESI 09 decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.Product Specifications
Molecular Weight
330.77
Formula
C16H15ClN4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
CAS Number
263707-16-0
PubChem ID
6077765
InChI Key
DXEATJQGQHDURZ-DEDYPNTBSA-N
SMILES
CC(C)(C)C1=CC(C(/C(C#N)=N/NC2=CC=CC(Cl)=C2)=O)=NO1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.08 | 100 | |
| Ethanol | 6.62 | 20 |
Preparing Stock Solutions
for ESI 09
The following data is based on the product molecular weight 330.77
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.02 mL | 15.12 mL | 30.23 mL |
| 5 mM | 0.60 mL | 3.02 mL | 6.05 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.02 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Almahariq A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 2013 PMID: 23066090
Product Specific Notices for ESI 09
For research use only
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