S1P1/EDG-1: Small Molecules and Peptides
EDG molecules are G protein-coupled receptors that bind plasma lysophospholipids. The EDG family consists of two subfamilies; the S1P (sphingosine-1-phosphate) subfamily consisting of EDG-1, 3, 5, 6, and 8, and the LPA (lysophosphatidic acid) subfamily that contains EDG-2, 4 and 7. Each receptor is the product of a distinct gene. The S1P family regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, and differentiation.
12 results for "S1P1/EDG-1 Small Molecules and Peptides" in Products
12 results for "S1P1/EDG-1 Small Molecules and Peptides" in Products
S1P1/EDG-1: Small Molecules and Peptides
EDG molecules are G protein-coupled receptors that bind plasma lysophospholipids. The EDG family consists of two subfamilies; the S1P (sphingosine-1-phosphate) subfamily consisting of EDG-1, 3, 5, 6, and 8, and the LPA (lysophosphatidic acid) subfamily that contains EDG-2, 4 and 7. Each receptor is the product of a distinct gene. The S1P family regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, and differentiation.
Cell-permeable, selective S1P1 receptor agonist
| Chemical Name: | 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole |
| Purity: | ≥98% (HPLC) |
Endogenous agonist at S1P1-5
| Chemical Name: | (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol |
| Purity: | ≥98% (HPLC) |
Selective S1P1 receptor agonist
| Chemical Name: | 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride |
| Purity: | ≥98% (HPLC) |
S1P1 and S1P3 antagonist
| Chemical Name: | 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide |
| Purity: | ≥95% (HPLC) |
Potent and selective S1P1 receptor antagonist; inhibits angiogenesis
| Chemical Name: | 3,4-Dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent S1P1 agonist
| Chemical Name: | N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective S1P1 receptor antagonist
| Alternate Names: | ML 056 |
| Chemical Name: | [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective S1P1 receptor antagonist
| Chemical Name: | 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid |
| Purity: | ≥98% (HPLC) |
Selective S1P1 agonist
| Chemical Name: | 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid |
| Purity: | ≥97% (HPLC) |
S1P1 and S1P5 agonist
| Chemical Name: | 4-[5-[5-Chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective S1P1 and S1P5 agonist
| Chemical Name: | 5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile |
| Purity: | ≥98% (HPLC) |
Potent S1P receptor agonist; also immunosuppressant
| Alternate Names: | Fingolimod,Gilenya |
| Chemical Name: | 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride |
| Purity: | ≥98% (HPLC) |
