PAR1: Small Molecules and Peptides
Human Proteinase-Activated Receptor 1 (hPAR1), also known as thrombin receptor, is a 65-70 kDa, 399 amino acid long member of the seven-transmembrane superfamily of cell-surface G protein-coupled receptors. PAR1 is activated by thrombin cleavage of its N-terminal propeptide in the extracellular domain. Human PAR1 is widely expressed in many cell types including endothelial cells, and it has been implicated in a variety of inflammatory responses. Over the regions used as immunogen, human and mouse PAR1 proteins are 58% identical in the region spanning the propeptide and extracellular domains, and 84% identical in the cytoplasmic tail.
5 results for "PAR1 Small Molecules and Peptides" in Products
5 results for "PAR1 Small Molecules and Peptides" in Products
PAR1: Small Molecules and Peptides
Human Proteinase-Activated Receptor 1 (hPAR1), also known as thrombin receptor, is a 65-70 kDa, 399 amino acid long member of the seven-transmembrane superfamily of cell-surface G protein-coupled receptors. PAR1 is activated by thrombin cleavage of its N-terminal propeptide in the extracellular domain. Human PAR1 is widely expressed in many cell types including endothelial cells, and it has been implicated in a variety of inflammatory responses. Over the regions used as immunogen, human and mouse PAR1 proteins are 58% identical in the region spanning the propeptide and extracellular domains, and 84% identical in the cytoplasmic tail.
PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist
| Alternate Names: | Thrombin receptor activator peptide 6 |
| Purity: | ≥95% (HPLC) |
Potent, selective non-peptide PAR1 antagonist
| Chemical Name: | N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
PAR1-activating peptide
| Purity: | ≥95% (HPLC) |
PAR1 antagonist
| Chemical Name: | 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester |
| Purity: | ≥98% (HPLC) |
Tryptase inhibitor
| Chemical Name: | N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide |
| Purity: | ≥95% (HPLC) |
