TRAP-6

Tocris Bioscience, part of Bio-Techne | Catalog # 3497

COA / SDS

PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist

Key Product Details

Description:	PAR₁ peptide fragment (residues 42-47); acts as a PAR₁ agonist
Alternative Names:	Thrombin receptor activator peptide 6
Purity:	≥95% (HPLC)
Molecular Weight:	748.88

View Full Technical Details for TRAP-6

Technical Data
Citations

Biological Activity for TRAP-6

TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR₁) that acts as a PAR₁ agonist. Stimulates platelet aggregation (EC₅₀ = 0.8 μM), promotes intracellular Ca²⁺ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.

Technical Data for TRAP-6

M. Wt	748.88
Formula	C₃₄H₅₆N₁₀O₉
Single Letter Sequence	SFLLRN
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	141136-83-6
PubChem ID	9831933
InChi Key	HAGOWCONESKMDW-FRSCJGFNSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TRAP-6

Solubility

Soluble to 1mg/ml in water

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References for TRAP-6

References are publications that support the biological activity of the product.

Kaufmann PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 1999 PMID: 10421070
Hunter Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 2009 PMID: 19261611
Vassallo Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 1992 PMID: 1313429