Skip to main content

8 results for "HIF Inhibitors Small Molecules and Peptides" in Products

HIF Inhibitors: Small Molecules and Peptides

Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in the cellular environment. They influence cell metabolism, cell survival and angiogenesis to maintain biological homeostasis. The HIF family is made up of α subunits (HIF-1, HIF-2 and HIF-3) and a constitutively expressed β subunit (ARNT; also known as Aryl hydrocarbon Receptor Nuclear Translocator).

The best characterized hypoxia response pathway is mediated ...

Show More

HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Purity: ≥98% (HPLC)
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Highly potent and selective HIF-1α inhibitor

Alternate Names: Quinomycin A
Chemical Name: N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
Purity: ≥98% (HPLC)
Highly potent and selective HIF-1α inhibitor

Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α

Alternate Names: CAY 10585
Chemical Name: Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate
Purity: ≥98% (HPLC)
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α

Prolyl hydroxylase inhibitor

Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Purity: ≥97% (HPLC)
Prolyl hydroxylase inhibitor

Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor

Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Purity: ≥98% (HPLC)
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor

HIF α-subunit inhibitor

Chemical Name: 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
Purity: ≥98% (HPLC)
HIF α-subunit inhibitor

Thioredoxin-1 inhibitor

Alternate Names: IV-2
Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole
Purity: ≥98% (HPLC)
Thioredoxin-1 inhibitor

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

Chemical Name: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Purity: ≥97% (HPLC)
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
Results Per Page
5 10 25 50
/ 1