8 results for "HIF Inhibitors Small Molecules and Peptides" in Products
HIF Inhibitors: Small Molecules and Peptides
Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in the cellular environment. They influence cell metabolism, cell survival and angiogenesis to maintain biological homeostasis. The HIF family is made up of α subunits (HIF-1, HIF-2 and HIF-3) and a constitutively expressed β subunit (ARNT; also known as Aryl hydrocarbon Receptor Nuclear Translocator).
The best characterized hypoxia response pathway is mediated ...
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
| Chemical Name: | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Highly potent and selective HIF-1α inhibitor
| Alternate Names: | Quinomycin A |
| Chemical Name: | N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether |
| Purity: | ≥98% (HPLC) |
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
| Alternate Names: | CAY 10585 |
| Chemical Name: | Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate |
| Purity: | ≥98% (HPLC) |
Prolyl hydroxylase inhibitor
| Chemical Name: | N-(2-Methoxy-2-oxoacetyl)glycine methyl ester |
| Purity: | ≥97% (HPLC) |
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
| Chemical Name: | N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine |
| Purity: | ≥98% (HPLC) |
HIF α-subunit inhibitor
| Chemical Name: | 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate |
| Purity: | ≥98% (HPLC) |
Thioredoxin-1 inhibitor
| Alternate Names: | IV-2 |
| Chemical Name: | 2-[(1-Methylpropyl)dithio]-1H-imidazole |
| Purity: | ≥98% (HPLC) |
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
| Chemical Name: | 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol |
| Purity: | ≥97% (HPLC) |
