Adaptaquin

Name: Adaptaquin
Brand: Tocris Bioscience
SKU: 5953

Tocris Bioscience, part of Bio-Techne | Catalog # 5953

Citations (3)

COA / SDS

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

Key Product Details

Description:	HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
Chemical Name:	7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Purity:	≥97% (HPLC)
Molecular Weight:	377.82

View Full Technical Details for Adaptaquin

Technical Data
Citations

Biological Activity for Adaptaquin

Adaptaquin is a HIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.

Technical Data for Adaptaquin

M. Wt	377.82
Formula	C₂₁H₁₆ClN₃O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	385786-48-1
PubChem ID	3740671
InChi Key	KKYHNYRUBSYTCZ-UHFFFAOYSA-N
Smiles	OC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Adaptaquin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.78	100

Preparing Stock Solutions for Adaptaquin

The following data is based on the product molecular weight 377.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.23 mL	26.47 mL
5 mM	0.53 mL	2.65 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for Adaptaquin

References are publications that support the biological activity of the product.

Neitemeier Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 PMID: 27148687
Karuppagounder Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci.Transl.Med. 2016 PMID: 26936506