DMOG

Name: DMOG
Brand: Tocris Bioscience
SKU: 4408
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4408

(2)

Citations (25)

COA / SDS

Prolyl hydroxylase inhibitor

Key Product Details

Description:	Prolyl hydroxylase inhibitor
Chemical Name:	N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Purity:	≥97% (HPLC)
Molecular Weight:	175.14

View Full Technical Details for DMOG

Technical Data
Citations / Reviews (2)

Biological Activity for DMOG

DMOG is a prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. Inhibits differentiation of hematopoietic stem cells (HSCs) in culture.

Technical Data for DMOG

M. Wt	175.14
Formula	C₆H₉NO₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	89464-63-1
PubChem ID	560326
InChi Key	BNJOZDZCRHCODO-UHFFFAOYSA-N
Smiles	O=C(C(OC)=O)NCC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DMOG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.51	100
	DMSO	17.51	100

Preparing Stock Solutions for DMOG

The following data is based on the product molecular weight 175.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.71 mL	28.55 mL	57.10 mL
5 mM	1.14 mL	5.71 mL	11.42 mL
10 mM	0.57 mL	2.85 mL	5.71 mL
50 mM	0.11 mL	0.57 mL	1.14 mL

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Reconstitution Calculator

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References for DMOG

References are publications that support the biological activity of the product.

Jackson Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res 2017 PMID: 28445828
Barnucz Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. J.Pharmacol.Exp.Ther. 2013 PMID: 23388095
Jaakkola Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O₂-regulated prolyl hydroxylation. Science 2001 PMID: 11292861
Lomb Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne Mol.Pharmacol. 2009 PMID: 19204094
Ayrapetov Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One 2011 PMID: 22016813