GN 44028

Name: GN 44028
Brand: Tocris Bioscience
SKU: 5655

Tocris Bioscience, part of Bio-Techne | Catalog # 5655

Citations (4)

COA / SDS

Potent HIF-1α inhibitor

Key Product Details

Description:	Potent HIF-1α inhibitor
Chemical Name:	N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Purity:	≥98% (HPLC)
Molecular Weight:	305.33

View Full Technical Details for GN 44028

Technical Data
Citations

Biological Activity for GN 44028

GN 44028 is a potent HIF-1α inhibitor (IC₅₀ = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.

Compound Libraries for GN 44028

GN 44028 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for GN 44028

M. Wt	305.33
Formula	C₁₈N₁₅N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1421448-26-1
PubChem ID	71625259
InChi Key	CGZKSZVSWAAUHE-UHFFFAOYSA-N
Smiles	C12=CC=CC=C1C3=C(C(NC4=CC(OCCO5)=C5C=C4)=NN3)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GN 44028

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.53	100
	ethanol	30.53	100

Preparing Stock Solutions for GN 44028

The following data is based on the product molecular weight 305.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.28 mL	16.38 mL	32.75 mL
5 mM	0.66 mL	3.28 mL	6.55 mL
10 mM	0.33 mL	1.64 mL	3.28 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for GN 44028

References are publications that support the biological activity of the product.

Minegishi Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 2013 PMID: 24900662