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CRBN: Small Molecules and Peptides

121 results for "CRBN Small Molecules and Peptides" in Products

121 results for "CRBN Small Molecules and Peptides" in Products

CRBN: Small Molecules and Peptides

Cereblon Degrader (PROTAC®)

Chemical Name: N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
Purity: ≥98% (HPLC)
Cereblon Degrader (PROTAC®)

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Chemical Name: (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥96% (HPLC)
Application of CRBN-6-5-5-VHL in MM1S cells for CRBN-6-5-5-VHL
(2)

Negative control for dTAG-13 (Cat. No. 6605)

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥97% (HPLC)
Negative control for dTAG-13 (Cat. No. 6605)

Binds cereblon; also TNF-α synthesis inhibitor

Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide
Purity: ≥98% (HPLC)
Binds cereblon; also TNF-α synthesis inhibitor

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Chemical Name: 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Purity: ≥98% (HPLC)
Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Fluoro functionalized Thalidomide; cereblon ligand for PROTACs

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione
Purity: ≥95%
Fluoro functionalized Thalidomide; cereblon ligand for PROTACs

α-synuclein Degrader (PROTAC®)

Chemical Name: 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity: ≥98% (HPLC)
α-synuclein PROTAC® Degrader

Potent and selective Wee1 Degrader (PROTAC®)

Chemical Name: 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: ≥98% (HPLC)
Potent and selective Wee1 Degrader (PROTAC®)

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity: ≥98% (HPLC)
Cereblon binder; induces ubiquitination and degradation of CK1α by  E3 ubiquitin ligase

Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Chemical Name: 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Cereblon ligand with terminal piperidine for onward chemistry

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-6-[4-(4-piperidinylmethyl)-1-piperazinyl]-1H-isoindole-1,3(2H)-dione dihydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with terminal piperidine for onward chemistry

Cereblon ligand with amine on C5 for onward chemistry

Chemical Name: 5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with amine on C5 for onward chemistry

Cereblon ligand with terminal piperazine for onward chemistry

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-5-(1-piperazinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with terminal piperazine for onward chemistry

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name: 3-[4-[[2-(2-Azidoethoxy)ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal azide for onward chemistry

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name: 5-[(10-Aminodecyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names: Pomalidomide - linker 3
Chemical Name: 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 4-(3-Azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name: 3-[4-[[2-[2-(2-Azidoethoxy)ethoxy]ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal azide for onward chemistry

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name: 8-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]octanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 4-[(2-Azidoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Chemical Name: 3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal acid for onward chemistry

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name: 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal azide for onward chemistry

Functionalized cereblon ligand for PROTAC development

Chemical Name: 2-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenoxy]acetic acid
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

Functionalized cereblon ligand for PROTAC development

Chemical Name: 3-[[3-(1-Piperazinyl)phenyl]amino]-2,6-piperidinedione dihydrochloride
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

Selective STING Degrader (PROTAC®)

Chemical Name: (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity: ≥98% (HPLC)
Selective STING Degrader (PROTAC®)
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