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Compounds for ESC/iPSC Proliferation and Renewal: Small Molecules and Peptides

18 results for "Compounds for ESC/iPSC Proliferation and Renewal Small Molecules and Peptides" in Products

18 results for "Compounds for ESC/iPSC Proliferation and Renewal Small Molecules and Peptides" in Products

Compounds for ESC/iPSC Proliferation and Renewal: Small Molecules and Peptides

Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

Alternate Names: y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor
Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
ROCK inhibition by Y-27632 and immunostaining of skeletal myogenic differentiation of MESP1+ mesoderm,
(8)

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99% (HPLC)
dopaminergic neurons derived from hiPSCs using SB 431542
(2)

Y-27632 synthesized to cGMP guidelines

Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥99%
Y-27632 synthesized to cGMP guidelines

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98% (HPLC)
Adult Stem Cell-derived Liver Organoids
(6)

PORCN inhibitor; inhibits Wnt processing and secretion

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity: ≥98% (HPLC)
iPSC-derived heart organoids differentiated with IWP 2 and CHIR 99021
(2)

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity: ≥99% (HPLC)
Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

Chemical Name: (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

Potent pan-caspase inhibitor

Chemical Name: N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
Purity: ≥98% (HPLC)
Potent pan-caspase inhibitor

MEK inhibitor

Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
MEK inhibitor

Potent GSK-3 inhibitor; also inhibits cdks

Alternate Names: 6BIO
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-oxime
Purity: ≥98% (HPLC)
Potent GSK-3 inhibitor; also inhibits cdks

Potent AMPK activator

Chemical Name: 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Purity: ≥98% (HPLC)
Potent AMPK activator

Sterile-filtered 10 mM solution of Y-27632, selective ROCK inhibitor, pre-dissolved in water

Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥97% (HPLC)
vial of Y-27632 in solution
(2)

Potent, selective GSK-3 inhibitor

Chemical Name: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Potent, selective GSK-3 inhibitor

Heparin sulfate antagonist

Chemical Name: N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride
Purity: ≥98% (HPLC)
Heparin sulfate antagonist

Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development

Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Purity: ≥95% (HPLC)
Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development

Potent and selective Lck and Src inhibitor; also inhibits SIK

Alternate Names: KIN112
Chemical Name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
Purity: ≥98% (HPLC)
Potent and selective Lck and Src inhibitor; also inhibits SIK

Enhances survival of human ESCs following enzymatic dissociation

Chemical Name: N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
Purity: ≥98% (HPLC)
Enhances survival of human ESCs following enzymatic dissociation

Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds

Purity: ≥95% (HPLC)
Potent integrin inhibitor (αVβ3/αVβ5); also improves stem cell attachment in 3D cell culture scaffolds
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