16,16-Dimethyl Prostaglandin E2
Tocris Bioscience, part of Bio-Techne | Catalog # 4027
Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development
Key Product Details
Description
Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development
Product Description
16,16-Dimethyl Prostaglandin E2 is a synthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.Product Specifications
Molecular Weight
380.52
Formula
C22H36O5
Storage
Store at -80°C
Purity
≥95% (HPLC)
Chemical Name
(5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
CAS Number
39746-25-3
PubChem ID
5283066
InChI Key
QAOBBBBDJSWHMU-WMBBNPMCSA-N
SMILES
O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble in methyl acetate (supplied pre-dissolved -10mg/ml) |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Heffner Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther. 2018 PMID: 29102562
- Goessling Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009 PMID: 19303855
- North Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 PMID: 17581586
- Lord Prostaglandin E2: making more of your marrow. Cell Cycle. 2007 PMID: 18075310
Product Specific Notices for 16,16-Dimethyl Prostaglandin E2
For research use only
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