Chemokine Receptor Agonists: Small Molecules and Peptides

Chemokine receptors are found predominantly on leukocytes and are important in leukocyte trafficking, as well as leukocyte-dependent processes such as immune surveillance, immune response and pathological inflammation. Chemokines have a role in angiogenesis, apoptosis, T-cell differentiation and phagocyte activation, while inappropriate or prolonged expression of chemokines and their receptors can lead to autoimmune disease by incorrectly targeting self antigens for destruction by cytotoxic ...