Chemerin-9, Human

Name: Chemerin-9, Human
Brand: Tocris Bioscience
SKU: 7116

Tocris Bioscience, part of Bio-Techne | Catalog # 7116

COA / SDS

Potent CMKLR1 agonist; c-terminal peptide of full length human chemerin

Key Product Details

Description:	Potent CMKLR1 agonist; c-terminal peptide of full length human chemerin
Purity:	≥95% (HPLC)
Molecular Weight:	1063.18

View Full Technical Details for Chemerin-9, Human

Technical Data
Citations

Biological Activity for Chemerin-9, Human

Chemerin-9, Human is a potent chemokine-like receptor 1 (CMKLR1; also known as chemerin receptor 23, ChemR23) agonist (EC₅₀ = 7.1 nM at CMKLR expressed in CHO cells). Corresponds to C-terminal of full length human Chemerin, amino acids 149 - 157. Activates G_i/o signaling pathways in vitro; inhibits cAMP production and promotes phospholipase C production and Ca²⁺ mobilization.

Technical Data for Chemerin-9, Human

M. Wt	1063.18
Formula	C₅₄H₆₆N₁₀O₁₃
Single Letter Sequence	YFPGQFAFS
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	676367-27-4
PubChem ID	11332190
InChi Key	QLVGSBXIQFERFK-NBBYSTNSSA-N
Smiles	O=C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=C(C=C5)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Chemerin-9, Human

Solubility

Soluble to 1mg/ml in water

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References for Chemerin-9, Human

References are publications that support the biological activity of the product.

De Henau Signaling properties of chemerin receptors CMKLR1, GPR1 and CCRL2. PLoS One. 2016 PMID: 27716822
Wittamer The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J.Med.Chem. 2004 PMID: 14701797