9 results for "Cav1.x Channel Blockers Small Molecules and Peptides" in Products
Cav1.x Channel Blockers: Small Molecules and Peptides
CaV1.x channels (L-type) are high-voltage activated Ca2+ channels that are sensitive to blockade by dihydropyridines. This family has four members, each composed of an α1, α2/δ, β and γ subunit.
CaV1.1 channels are specific to skeletal muscle where they interact with ryanodine receptors on the sarcoplasmic reticulum and trigger Ca2+ influx, Ca2+-activated Ca2+ release and muscle contraction. Mutations in CaV1.1 α1-subunit have been linked to hypokalemic periodic ...
CaV1.x blocker
| Chemical Name: | 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester |
| Purity: | ≥98% (HPLC) |
CaV1.x blocker
| Chemical Name: | α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride |
| Purity: | ≥98% (HPLC) |
CaV1.x blocker
| Chemical Name: | (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride |
| Purity: | ≥98% (HPLC) |
CaV1.x blocker
| Alternate Names: | Norvasc |
| Chemical Name: | 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate |
| Purity: | ≥98% (HPLC) |
CaV1.x blocker
| Alternate Names: | PN 200-110 |
| Chemical Name: | 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester |
| Purity: | ≥98% (HPLC) |
CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor
| Chemical Name: | (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester |
| Purity: | ≥98% (HPLC) |
CaV1.x blocker
| Chemical Name: | 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester |
| Purity: | ≥98% (HPLC) |
Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable
| Alternate Names: | AMG 073 |
| Chemical Name: | N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker
| Chemical Name: | N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride |
| Purity: | ≥98% (HPLC) |
