Isradipine

Product Description

Isradipine is a potent and selective L-type voltage-gated Ca²⁺ channel blocker. EC₅₀ and pA₂ values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca²⁺-induced contractions of rabbit aorta respectively; EC₂₅ = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.

Solubility

Preparing Stock Solutions for Isradipine

The following data is based on the product molecular weight 371.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.39 mL	26.93 mL	53.85 mL
2.5 mM	1.08 mL	5.39 mL	10.77 mL
5 mM	0.54 mL	2.69 mL	5.39 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wada Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart. J.Cardiovasc.Pharmacol. 1985 PMID: 2580142
• Ruegg and Hof Pharmacology of the calcium antagonist israd. Drugs
• Hof PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. J.Cardiovasc.Pharmacol. 1984 PMID: 6202964