Amlodipine besylate

Name: Amlodipine besylate
Brand: Tocris Bioscience
SKU: 2571
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2571

(1)

Citations (5)

COA / SDS

CaV1.x blocker

Key Product Details

Description:	Ca_V1.x blocker
Alternative Names:	Norvasc
Chemical Name:	2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	567.05

View Full Technical Details for Amlodipine besylate

Technical Data
Citations / Reviews (1)

Biological Activity for Amlodipine besylate

Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).

Compound Libraries for Amlodipine besylate

Amlodipine besylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Amlodipine besylate

M. Wt	567.05
Formula	C₂₀H₂₅ClN₂O₅.C₆H₆O₃S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	111470-99-6
PubChem ID	60496
InChi Key	ZPBWCRDSRKPIDG-UHFFFAOYSA-N
Smiles	OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amlodipine besylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	56.7	100

Preparing Stock Solutions for Amlodipine besylate

The following data is based on the product molecular weight 567.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.82 mL	17.64 mL
5 mM	0.35 mL	1.76 mL	3.53 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for Amlodipine besylate

References are publications that support the biological activity of the product.

Yoshida Antiproliferative effect of Ca²⁺ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 2003 PMID: 12860469
Toba Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the NG-nitro-L-arginine methyl ester-induced hype Hypertens.Res. 2005 PMID: 16392774
Burges Calcium channel blocking properties of amlod. in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol. 1987 PMID: 2434785