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20 results for "Caspase Inhibitors" in Products

Caspase Inhibitors Products

Caspases (cysteinyl aspartate proteases) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED.

Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are ...

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Caspase-3 Inhibitor

Purity: ≥95% (HPLC)
Caspase-3 Inhibitor

Cell-permeable, irreversible caspase inhibitor

Chemical Name: Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Purity: ≥95% (HPLC)
Cell-permeable, irreversible caspase inhibitor

Potent pan-caspase inhibitor

Chemical Name: N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
Purity: ≥98% (HPLC)
Potent pan-caspase inhibitor

Caspase-1 and NLRP3 inflammasome inhibitor

Chemical Name: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
Purity: ≥98% (HPLC)
Caspase-1 and NLRP3 inflammasome inhibitor

High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable

Alternate Names: Belnacasan
Chemical Name: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide
Purity: ≥98% (HPLC)
High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable

Potent and selective inhibitor of caspases 1, 5 and 4

Purity: ≥95% (HPLC)
Potent and selective inhibitor of caspases 1, 5 and 4

NLRP3 inhibitor; active in vivo

Chemical Name: 4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
Purity: ≥98% (HPLC)
NLRP3 inhibitor; active in vivo
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