APP: Small Molecules and Peptides
Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.
Products:
9 results for "APP Small Molecules and Peptides" in Products
9 results for "APP Small Molecules and Peptides" in Products
APP: Small Molecules and Peptides
Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.
Products:
Predominant amyloid β-protein fragment
| Purity: | ≥95% (HPLC) |
Brain penetrant fluorescent amyloid β probe. Used for: detection and quantification of plaques, tangles and cerebrovascular amyloid. Application: confocal microscopy, suitable for in vivo imaging
| Chemical Name: | 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol |
| Purity: | ≥98% (HPLC) |
Amyloid β-protein fragment
| Purity: | ≥95% (HPLC) |
STAT3 activator; also protects against β-amyloid neurotoxicity
| Purity: | ≥95% (HPLC) |
β-secretase (BACE) inhibitor; inhibits amyloid assembly
| Alternate Names: | Epigallocatechin gallate |
| Chemical Name: | 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester |
| Purity: | ≥98% (HPLC) |
Inhibitor of Aβ42 fibril formation
| Chemical Name: | 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine |
| Purity: | ≥98% (HPLC) |
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
| Chemical Name: | 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide |
| Purity: | ≥98% (HPLC) |
Potent and selective ERβ agonist; neuroprotective
| Chemical Name: | 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol |
| Purity: | ≥98% (HPLC) |
Antiallergic; inhibits inflammatory mediator release from mast cells
| Chemical Name: | 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid |
| Purity: | ≥98% (HPLC) |
