Ro 90-7501
Tocris Bioscience, part of Bio-Techne | Catalog # 2408
Inhibitor of Aβ42 fibril formation
Key Product Details
Description
Inhibitor of Aβ42 fibril formation
Product Description
Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).Product Specifications
Molecular Weight
340.39
Formula
C20H16N6
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine
CAS Number
293762-45-5
PubChem ID
824226
InChI Key
PAGZCEHLFCJSPV-UHFFFAOYSA-N
SMILES
NC1=CC=C(C=C1)C1=NC2=CC=C(C=C2N1)C1=NC2=CC=C(N)C=C2N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 3.4 | 10 | |
| DMSO | 34.04 | 100 |
Preparing Stock Solutions
for Ro 90-7501
The following data is based on the product molecular weight 340.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.69 mL | 29.38 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bohrmann Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J.Struct.Biol. 2000 PMID: 10940228
Product Specific Notices for Ro 90-7501
For research use only
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