J 147
Tocris Bioscience, part of Bio-Techne | Catalog # 5081
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
Key Product Details
Description
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
Product Description
J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.Licensing Information
Sold for research use only under license from the Salk Institute for Biological StudiesProduct Specifications
Molecular Weight
350.33
Formula
C18H17F3N2O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
CAS Number
1146963-51-0
PubChem ID
25229652
InChI Key
HYMZAYGFKNNHDN-SSDVNMTOSA-N
SMILES
O=C(C(F)(F)F)N(C2=C(C)C=C(C)C=C2)/N=C/C1=CC=CC(OC)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.03 | 100 | |
| Ethanol | 35.03 | 100 |
Preparing Stock Solutions
for J 147
The following data is based on the product molecular weight 350.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Prior The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimer's.Res.Ther. 2013 PMID: 23673233
- Chiruta Metabolism of a potent neuroprotective hydrazide. Bioorg.Med.Chem. 2013 PMID: 23582448
- Chen A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One 2011 PMID: 22194796
Product Specific Notices for J 147
For research use only
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