8 results for "VEGFR1, VEGFR2, VEGFR3" in Products
VEGFR1, VEGFR2, VEGFR3 Products
VEGFR1 (Flt-1), VEGFR2 (KDR/Flk-1), and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGFR2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGFR3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Potent FGFR and VEGFR inhibitor
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
Potent VEGFR-1, -2 and -3 inhibitor
Potent VEGFR, PDGFRβ and KIT inhibitor
Potent EGFR and VEGFR inhibitor
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
Potent VEGFR inhibitor; also aromatase inhibitor
1 vial each of PE-conjugated anti-VEGF R1 (clone 49560), VEGF R2 (clone 89106), and VEGF R3 (clone 54733)