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5 results for "TNF-alpha" in Products

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TNF-alpha Products

TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells. It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor ...

Bay 11-7085

Catalog #: 1743

Product Documents

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Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

Alternate Names:

Bay 11-7083

Chemical Name:

(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile

Purity:

≥98%

Thalidomide

Catalog #: 0652

Product Documents

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Binds cereblon; also TNF-α synthesis inhibitor

Chemical Name:

N-(2,6-dioxo-3-piperidinyl)phthalimide

Purity:

≥98%

Celastrol

Catalog #: 3203

Product Documents

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Inhibits TNF-α-induced NF-κB activation

Chemical Name:

(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid

Purity:

≥98%

KIN001-266

Catalog #: 6984

Product Documents

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Potent and selective Tpl2 (MAP3K8) inhibitor

Chemical Name:

8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile

Purity:

≥98%

RIPA 56

Catalog #: 7339

Product Documents

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Potent and metabolically stable RIP1 kinase inhibitor

Chemical Name:

N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide

Purity:

≥98%

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