KIN001-266
Tocris Bioscience, part of Bio-Techne | Catalog # 6984
Potent and selective Tpl2 (MAP3K8) inhibitor
Key Product Details
Description
Potent and selective Tpl2 (MAP3K8) inhibitor
Product Description
KIN001-266 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 1.6 nM). It exhibits 6875-fold selectivity over EGFR. In vivo, it inhibits TNF-α production in a LPS-stimulated rat inflammation model. KIN001-266 is orally bioavailable.Product Specifications
Molecular Weight
539.44
Formula
C26H25Cl2FN8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile
CAS Number
915363-56-3
PubChem ID
44143370
InChI Key
PHNZIIMWDVXPGG-UHFFFAOYSA-N
SMILES
CCN1CCC(N2C=C(N=N2)CNC3=CC4=C(C(Cl)=C3)N=CC(C#N)=C4NC5=CC(Cl)=C(C=C5)F)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.94 | 100 | |
| Ethanol | 10.79 | 20 |
Preparing Stock Solutions
for KIN001-266
The following data is based on the product molecular weight 539.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.85 mL | 9.27 mL | 18.54 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.85 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wu Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg.Med.Chem.Lett. 2009 PMID: 19464884
- Glatthar Discovery of imidazoquinolines as a novel class of potent, selective, and in vivo efficacious Cancer Osaka Thyroid (COT) kinase inhibitors. J.Med.Chem. 2016 PMID: 27502541
Product Specific Notices for KIN001-266
For research use only
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