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12 results for "PARP" in Products

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PARP Products

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

XAV 939

Catalog #: 3748

(1)

Citations (410)

Product Documents

Images (1)

Potent tankyrase inhibitor

GMP Version Available: TB3748-GMP

GMP

Alternate Names:

XAV939 Wnt Signaling Inhibitor

Chemical Name:

3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

Purity:

≥98%

Nicotinamide

Catalog #: 4106

(1)

Citations (63)

Product Documents

Images (5)

PARP-1 inhibitor

Chemical Name:

Pyridine-3-carboxamide

Purity:

≥99%

EB 47

Catalog #: 4140

(1)

Citations (6)

Product Documents

Images (1)

Potent PARP-1 inhibitor

Chemical Name:

5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride

Purity:

≥98%

Olaparib

Catalog #: 7579

(1)

Citations (21)

Product Documents

Images (1)

Potent PARP inhibitor

Chemical Name:

4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone

Purity:

≥98%

PJ 34 hydrochloride

Catalog #: 3255

Citations (3)

Product Documents

Images (1)

Potent PARP inhibitor

Chemical Name:

N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride

Purity:

≥98%

AZD 2461

Catalog #: 6060

Citations (4)

Product Documents

Images (1)

Potent PARP inhibitor; orally bioavailable

Chemical Name:

4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone

Purity:

≥98%

Rucaparib camsylate

Catalog #: 6230

Citations (2)

Product Documents

Images (1)

PARP inhibitor

Alternate Names:

CO-338

Chemical Name:

8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid

Purity:

≥98%