BGP 15

Name: BGP 15
Brand: Tocris Bioscience
SKU: 6703

Tocris Bioscience, part of Bio-Techne | Catalog # 6703

Citations (2)

COA / SDS

PARP inhibitor; cytoprotectant

Key Product Details

Description:	PARP inhibitor; cytoprotectant
Chemical Name:	N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	351.27

View Full Technical Details for BGP 15

Technical Data
Citations

Biological Activity for BGP 15

BGP 15 is a PARP inhibitor (IC₅₀ = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. BGP 15 also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.

Technical Data for BGP 15

M. Wt	351.27
Formula	C₁₄H₂₂N₄O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	66611-37-8
PubChem ID	70701185
InChi Key	ISGGVCWFTPTHIX-UHFFFAOYSA-N
Smiles	OC(CN1CCCCC1)CONC(C2=CN=CC=C2)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BGP 15

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	35.13	100
	DMSO	7.03	20 with gentle warming

Preparing Stock Solutions for BGP 15

The following data is based on the product molecular weight 351.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.47 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for BGP 15

References are publications that support the biological activity of the product.

Chung HSP72 protects against obesity-induced insulin resistance. Proc.Natl.Acad.Sci.U.S.A 2008 PMID: 18223156
Ohlen BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia. Proc.Natl.Acad.Sci.U.S.A 2017 PMID: 28439028
Racz BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Biochem.Pharmacol. 2002 PMID: 11931842
Henstridge Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 2014 PMID: 24430435
Szabados BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem.Pharmacol. 2000 PMID: 10692558