Osteopontin/OPN Products
Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell adhesion, and migration. Its expression is upregulated during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.
580 results for "Osteopontin/OPN" in Products
580 results for "Osteopontin/OPN" in Products
Osteopontin/OPN Products
Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell adhesion, and migration. Its expression is upregulated during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, ICC, Neut |
| Sensitivity: | 0.024 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.312 - 20 ng/mL (Cell Culture Supernates, EDTA Plasma, Heparin Plasma, Urine, Human Milk) |
| Sensitivity: | 8.5 pg/mL |
| Applications: | ELISA |
| Assay Range: | 39 - 2,500 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
(OPN-b)
| Source: | NS0 |
| Accession #: | NP_000573.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q547B5 |
| Applications: | BA |
Simple Plex Mouse/Rat Osteopontin/OPN assay kit for use on Ella instrument. Contains cartridge, sample diluent SD09, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | ELISA, IHC, Dual ISH-IHC, ICC, Neut |
| Assay Range: | 62.5 - 4,000 pg/mL |
| Applications: | ELISA |
Control for use with Human Osteopontin/OPN Simple Plex Cartridge Kit
| Applications: | Ctrl, Simple Plex |
Control for use with Mouse/Rat Osteopontin/OPN Simple Plex Cartridge Kit
| Applications: | Ctrl, Simple Plex |
Simple Plex Cartridge Kit for quantitation of OPN. Contains cartridge, sample diluent SD13, and wash buffer
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #190312 |
| Applications: | IHC |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #223126 |
| Applications: | WB, Simple Western |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2579A |
| Applications: | IHC, ICC, Neut |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #223126 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #223126 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC |
Recombinant Monoclonal Antibody.
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #2139B |
| Applications: | WB, IHC, ICC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #223112R |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Rabbit Serum Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
![Western Blot: Osteopontin/OPN Antibody [NB600-1043]](https://resources.bio-techne.com/images/products/Osteopontin-OPN-Antibody-Western-Blot-NB600-1043-img0009.jpg "Western Blot: Osteopontin/OPN Antibody [NB600-1043]")
| Source: | Bovine Milk |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat, Rabbit |
| Details: | Mouse IgG1 Monoclonal Clone #1B20 |
| Applications: | IHC, WB, ICC/IF, IP, Simple Western |
![Western Blot: Osteopontin/OPN Antibody (1B20)Azide and BSA Free [NBP2-80895]](https://resources.bio-techne.com/images/products/Osteopontin-OPN-Antibody-1B20-Azide-and-BSA-Free-Western-Blot-NBP2-80895-img0001.jpg "Western Blot: Osteopontin/OPN Antibody (1B20)Azide and BSA Free [NBP2-80895]")