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10 results for "KOR Small Molecules and Peptides" in Products

KOR: Small Molecules and Peptides

Kappa Opioid Receptor (KOR) is a 45 kDa 7TM opioid receptor that is primarily expressed in the central nervous system and peripheral visceral pain sensory nerves. Following ligation by dynorphin peptides, KOR signaling induces analgesia, dysphoria, diuresis, and increased feeding desire. KOR also exerts neuroprotective and anti-inflammatory effects. Human KOR shares 94% amino acid sequence identity with mouse and rat KOR.

Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)

Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)

Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495)

Chemical Name: trans-(+)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495)

Activator of κ-opioid DREADD (KORD)

Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Activator of κ-opioid DREADD (KORD)

κ agonist, acts peripherally

Chemical Name: (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
Purity: ≥98% (HPLC)
κ agonist, acts peripherally

Opioid receptor antagonist

Chemical Name: (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
Purity: ≥98% (HPLC)
Opioid receptor antagonist

Selective κ opioid receptor antagonist

Chemical Name: N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide
Purity: ≥98% (HPLC)
Selective κ opioid receptor antagonist

Subtype-selective κ agonist

Chemical Name: 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
Purity: ≥99% (HPLC)
Subtype-selective κ agonist

Endogenous κ agonist

Purity: ≥95% (HPLC)
Endogenous κ agonist

Selective and irreversible κ antagonist

Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥98% (HPLC)
Selective and irreversible κ antagonist

Selective κ agonist

Chemical Name: trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Selective κ agonist
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