Salvinorin B
Tocris Bioscience, part of Bio-Techne | Catalog # 5611
Activator of κ-opioid DREADD (KORD)
Product Description
Salvinorin B is a potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A.Product Specifications
Molecular Weight
390.43
Formula
C21H26O7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
CAS Number
92545-30-7
PubChem ID
11440685
InChI Key
BLTMVAIOAAGYAR-CEFSSPBYSA-N
SMILES
O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.81 | 20 |
Preparing Stock Solutions
for Salvinorin B
The following data is based on the product molecular weight 390.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.81 mL | 64.03 mL | 128.06 mL |
| 1 mM | 2.56 mL | 12.81 mL | 25.61 mL |
| 2 mM | 1.28 mL | 6.40 mL | 12.81 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ansonoff Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16672569
- Vardy A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 2015 PMID: 25937170
Product Specific Notices for Salvinorin B
For research use only
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