3 results for "IRE1 Inhibitors" in Products
IRE1 Inhibitors Products
Inositol-requiring enzyme 1 (IRE1), also known as endoplasmic reticulum to nucleus signaling 1 (ERN1), is a resident transmembrane ER protein with both kinase and endonuclease domains. Both yeast (IRE1) and mammalian (IRE1α) homologs are involved in the degradation of misfolded proteins, as part of the unfolded protein response (UPR). IRE1 (yeast) is involved in the endonucleolytic cleavage of HAC1 mRNA, whereas IRE1α (human) catalyzes the splicing of X-box binding protein (XBP) 1 ...
IRE1 endonuclease inhibitor; cell permeable
| Chemical Name: | 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one |
| Purity: | ≥98% (HPLC) |
Potent and selective IRE1α inhibitor
| Chemical Name: | 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Inhibits IRE1α endoribonuclease activity
| Chemical Name: | 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde |
| Purity: | ≥98% |
