AMG 18 hydrochloride

Name: AMG 18 hydrochloride
Brand: Tocris Bioscience
SKU: 6166

Tocris Bioscience, part of Bio-Techne | Catalog # 6166

Citations (4)

COA / SDS

Potent and selective IRE1α inhibitor

Key Product Details

Description:	Potent and selective IRE1α inhibitor
Chemical Name:	2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	637.58

View Full Technical Details for AMG 18 hydrochloride

Technical Data
Citations

Biological Activity for AMG 18 hydrochloride

AMG 18 hydrochloride is a potent and selective IRE1α inhibitor (IC₅₀ values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.

Technical Data for AMG 18 hydrochloride

M. Wt	637.58
Formula	C₃₁H₂₉ClN₆O₃S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250019-92-0
PubChem ID	134160238
InChi Key	CNWIPRHGMZTPSB-BOXHHOBZSA-N
Smiles	CC1=C(C2=C(C(NS(=O)(C3=C(C=CC=C3)Cl)=O)=CC=C2)C=C1)OC4=C(C5=NC(N[C@H]6CCCNC6)=NC=C5)C=CC=N4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG 18 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	63.76	100
	DMSO	63.76	100

Preparing Stock Solutions for AMG 18 hydrochloride

The following data is based on the product molecular weight 637.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.57 mL	7.84 mL	15.68 mL
5 mM	0.31 mL	1.57 mL	3.14 mL
10 mM	0.16 mL	0.78 mL	1.57 mL
50 mM	0.03 mL	0.16 mL	0.31 mL

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References for AMG 18 hydrochloride

References are publications that support the biological activity of the product.

Harrington Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 2014 PMID: 25589933