B I09
Tocris Bioscience, part of Bio-Techne | Catalog # 6009
IRE1 endonuclease inhibitor; cell permeable
Key Product Details
Description
IRE1 endonuclease inhibitor; cell permeable
Product Description
B I09 is an IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.Product Specifications
Molecular Weight
303.31
Formula
C16H17NO5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
CAS Number
1607803-67-7
PubChem ID
86290458
InChI Key
UYYMWNUDIOPESF-UHFFFAOYSA-N
SMILES
OC1=CC=C2C3=C(C(OC2=C1C4OCCCO4)=O)CNCC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.17 | 50 |
Preparing Stock Solutions
for B I09
The following data is based on the product molecular weight 303.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.59 mL | 32.97 mL | 65.94 mL |
| 2.5 mM | 1.32 mL | 6.59 mL | 13.19 mL |
| 5 mM | 0.66 mL | 3.30 mL | 6.59 mL |
| 25 mM | 0.13 mL | 0.66 mL | 1.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tang Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 2014 PMID: 24812669
Product Specific Notices for B I09
For research use only
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