B I09

Name: B I09
Brand: Tocris Bioscience
SKU: 6009

Tocris Bioscience, part of Bio-Techne | Catalog # 6009

Citations (6)

COA / SDS

IRE1 endonuclease inhibitor; cell permeable

Key Product Details

Description:	IRE1 endonuclease inhibitor; cell permeable
Chemical Name:	7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
Purity:	≥98% (HPLC)
Molecular Weight:	303.31

View Full Technical Details for B I09

Technical Data
Citations

Biological Activity for B I09

B I09 is an IRE-1 RNase inhibitor (IC₅₀ = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

Compound Libraries for B I09

B I09 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for B I09

M. Wt	303.31
Formula	C₁₆H₁₇NO₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1607803-67-7
PubChem ID	86290458
InChi Key	UYYMWNUDIOPESF-UHFFFAOYSA-N
Smiles	OC1=CC=C2C3=C(C(OC2=C1C4OCCCO4)=O)CNCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for B I09

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	15.17	50

Preparing Stock Solutions for B I09

The following data is based on the product molecular weight 303.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.59 mL	32.97 mL	65.94 mL
2.5 mM	1.32 mL	6.59 mL	13.19 mL
5 mM	0.66 mL	3.30 mL	6.59 mL
25 mM	0.13 mL	0.66 mL	1.32 mL

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References for B I09

References are publications that support the biological activity of the product.

Tang Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 2014 PMID: 24812669