Integrin alpha 4 beta 7/LPAM-1: Small Molecules and Peptides
Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin.
The chemokine receptor CCR9 and a4b7, both critical for homing to the intestinal mucosa, are induced during T cell activation in Peyer’s patches or mesenteric lymph nodes. a4b7-expressing Treg, memory T cells, and B cells home to the intestinal mucosa or the peritoneum. The HIV-1 envelope protein gp120 binds to the active form of a4b7 and may concentrate the virus in gut-associated lymphoid tissue (GALT).
Products:
5 results for "Integrin alpha 4 beta 7/LPAM-1 Small Molecules and Peptides" in Products
5 results for "Integrin alpha 4 beta 7/LPAM-1 Small Molecules and Peptides" in Products
Integrin alpha 4 beta 7/LPAM-1: Small Molecules and Peptides
Integrin alpha 4 beta 7 (LPAM-1) is an integrin family adhesion receptor that shares subunits with VLA4 and the E-cadherin receptor. It is the non-covalent heterodimer of alpha 4/CD49d and beta 7 transmembrane subunits. Motifs within a4b7 bind to metal ions and regulate cell adhesion functions. a4b7 binds the mucosal addressin MAdCAM-1, as well as VCAM-1 and Fibronectin.
The chemokine receptor CCR9 and a4b7, both critical for homing to the intestinal mucosa, are induced during T cell activation in Peyer’s patches or mesenteric lymph nodes. a4b7-expressing Treg, memory T cells, and B cells home to the intestinal mucosa or the peritoneum. The HIV-1 envelope protein gp120 binds to the active form of a4b7 and may concentrate the virus in gut-associated lymphoid tissue (GALT).
Products:
| Chemical Name: | (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid |
| Purity: | ≥98% (HPLC) |
| Chemical Name: | (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid |
| Purity: | ≥98% (HPLC) |
| Chemical Name: | 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid |
| Purity: | ≥98% (HPLC) |
